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ポリグルタミン媒介性神経毒性に対する生理活性化合物を発見するためのモデルシステムとしてのCaenorhabditis elegans
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
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ポリグルタミン媒介性神経毒性に対する生理活性化合物を発見するためのモデルシステムとしてのCaenorhabditis elegans

日本語

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3,021 Views

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08:16 min

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September 21, 2021

DOI:

10.3791/63081-v

DOI:
10.3791/63081-v

•

08:16 min
September 21, 2021

•

3 Views
, , , , , ,
1Institute for Food Nutrition and Human Health, School of Food Science and Engineering,South China University of Technology, 2School of Bioscience and Bioengineering,Hebei University of Economics and Business, 3Perfect Life & Health Institute

Summary

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ここでは、ポリグルタミン凝集、神経細胞死、および化学回避行動を含む Caenorhabditis elegansにおける試験化合物の神経保護活性を評価するためのプロトコル、ならびに複数の表現型の例示的な統合を提示する。

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Cite this Article

Wang, Q., Zhang, J., Jiang, Y., Xiao, Y., Li, X., Mao, X., Huang, Z. Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity. J. Vis. Exp. (175), e63081, doi:10.3791/63081 (2021).

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