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Chapters
- 00:04Introduction
- 00:51Generation of Acute Experimental Model of Motor Tic Expression in a Rat
- 02:38Generation of Chronic Experimental Model of Motor Tic Expression in a Rat
- 04:32Implantation of Chronic Model (Osmotic Pump) into the Rat
- 06:19Results: Tic Expression in Both Models
- 07:11Conclusion
Vi præsenterer protokoller til generering af akutte og kroniske eksperimentelle modeller af tic udtryk i frit at opføre rotter. Modellerne er baseret på striatal kanyle implantation og efterfølgende GABAA antagonist ansøgning. Den akutte model bruger forbigående injektioner, mens den kroniske model udnytter langvarige infusioner via en subkutan implanteret mini-osmotisk pumpe.
