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標的薬物送達のためのドキソルビシンを装填したアプタマー-PEI-G-PEG改変金ナノ粒子の合成
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Chemistry
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JoVE Journal Chemistry
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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標的薬物送達のためのドキソルビシンを装填したアプタマー-PEI-G-PEG改変金ナノ粒子の合成

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5,613 Views

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09:09 min

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June 23, 2020

DOI:

10.3791/61139-v

DOI:
10.3791/61139-v

•

09:09 min
June 23, 2020

•

6 Views
, , , , , ,
1College of Life Sciences,Xinyang Normal University, 2Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery,University Hospitals Leuven, 3Analysis & Testing Center,Xinyang Normal University

Summary

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このプロトコルでは、ドキソルビシンを装填したAS1411-g-PEI-g-PEG変性金ナノ粒子は、3段階のアミド反応を介して合成される。次いで、ドキソルビシンをロードし、癌治療のために標的癌細胞に送達する。

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Cite this Article

Nie, L., Sun, S., Sun, M., Zhou, Q., Zhang, Z., Zheng, L., Wang, L. Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery. J. Vis. Exp. (160), e61139, doi:10.3791/61139 (2020).

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