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Sintesi di Nanoparticelle d'oro modificate Aptamer-PEI-g-PEG Caricate con doxorubicina per la consegna mirata di farmaci
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Chemistry
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JoVE Journal Chemistry
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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Sintesi di Nanoparticelle d'oro modificate Aptamer-PEI-g-PEG Caricate con doxorubicina per la consegna mirata di farmaci

italiano

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5,616 Views

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09:09 min

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June 23, 2020

DOI:

10.3791/61139-v

DOI:
10.3791/61139-v

•

09:09 min
June 23, 2020

•

6 Views
, , , , , ,
1College of Life Sciences,Xinyang Normal University, 2Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery,University Hospitals Leuven, 3Analysis & Testing Center,Xinyang Normal University

Summary

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In questo protocollo, le nanoparticelle d'oro modificate AS1411-g-PEI-g-PEG caricate con doxorubicina vengono sintetizzati tramite reazioni di ammide in tre step. Quindi, la doxorubicina viene caricata e consegnata alle cellule tumorali bersaglio per la terapia del cancro.

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Cite this Article

Nie, L., Sun, S., Sun, M., Zhou, Q., Zhang, Z., Zheng, L., Wang, L. Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery. J. Vis. Exp. (160), e61139, doi:10.3791/61139 (2020).

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