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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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化学
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JoVE Journal 化学
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

5,616 Views

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09:09 min

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June 23, 2020

DOI:

10.3791/61139-v

DOI:
10.3791/61139-v

•

09:09 min
June 23, 2020

•

6 Views
, , , , , ,
1College of Life Sciences,Xinyang Normal University, 2Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery,University Hospitals Leuven, 3Analysis & Testing Center,Xinyang Normal University

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In this protocol, doxorubicin-loaded AS1411-g-PEI-g-PEG modified gold nanoparticles are synthesized via three-step amide reactions. Then, doxorubicin is loaded and delivered to target cancer cells for cancer therapy.

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DoxorubicinDrug DeliveryGold NanoparticlesAptamerPEI-g-PEGCT-PEGTargeted Drug DeliveryCancer TreatmentDrug ResistanceToxicity

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Cite this Article

Nie, L., Sun, S., Sun, M., Zhou, Q., Zhang, Z., Zheng, L., Wang, L. Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery. J. Vis. Exp. (160), e61139, doi:10.3791/61139 (2020).

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