Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Anna  H. F. Andersen; Stine  S. F. Nielsen; Rikke Olesen; Katharina Mack; Frederik Dagn&#230;s-Hansen; Niels Uldbjerg; Lars &#216;stergaard; Ole  S. S&#248;gaard; Paul  W. Denton; Martin Tolstrup

doi:10.3791/60723

Journal

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Immunology and Infection

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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

8,309 Views

•

08:15 min

•

January 31, 2020

DOI:

10.3791/60723-v

DOI:

10.3791/60723-v

•

08:15 min

January 31, 2020

•

3 Views

Anna H. F. Andersen^1,2, Stine S. F. Nielsen^1,2, Rikke Olesen^1,2, Katharina Mack¹, Frederik Dagnæs-Hansen³, Niels Uldbjerg^1,4, Lars Østergaard^1,2, Ole S. Søgaard^1,2, Paul W. Denton^1,2,5, Martin Tolstrup^1,2

¹Department of Clinical Medicine,Aarhus University, ²Department of Infectious Diseases,Aarhus University Hospital, ³Department of Biomedicine,Aarhus University, ⁴Department of Gynecology and Obstetrics,Aarhus University Hospital, ⁵Department of Biology,University of Nebraska at Omaha

Summary

We have developed a protocol for the generation and evaluation of a humanized and human immunodeficiency virus-infected NOG mouse model based on stem cell transplant, intravaginal human immunodeficiency virus exposure, and droplet digital PCR RNA quantification.

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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

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