Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Anna  H. F. Andersen; Stine  S. F. Nielsen; Rikke Olesen; Katharina Mack; Frederik Dagn&#230;s-Hansen; Niels Uldbjerg; Lars &#216;stergaard; Ole  S. S&#248;gaard; Paul  W. Denton; Martin Tolstrup

doi:10.3791/60723

Journal

/

Inmunología y contagio

/

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

JoVE Revista
Inmunología y contagio

Se requiere una suscripción a JoVE para ver este contenido. Inicie sesión o comience su prueba gratuita.

JoVE Revista Inmunología y contagio

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

8,310 Views

•

08:15 min

•

January 31, 2020

DOI:

10.3791/60723-v

DOI:

10.3791/60723-v

•

08:15 min

January 31, 2020

•

3 Views

Anna H. F. Andersen^1,2, Stine S. F. Nielsen^1,2, Rikke Olesen^1,2, Katharina Mack¹, Frederik Dagnæs-Hansen³, Niels Uldbjerg^1,4, Lars Østergaard^1,2, Ole S. Søgaard^1,2, Paul W. Denton^1,2,5, Martin Tolstrup^1,2

¹Department of Clinical Medicine,Aarhus University, ²Department of Infectious Diseases,Aarhus University Hospital, ³Department of Biomedicine,Aarhus University, ⁴Department of Gynecology and Obstetrics,Aarhus University Hospital, ⁵Department of Biology,University of Nebraska at Omaha

Summary

We have developed a protocol for the generation and evaluation of a humanized and human immunodeficiency virus-infected NOG mouse model based on stem cell transplant, intravaginal human immunodeficiency virus exposure, and droplet digital PCR RNA quantification.

Explore More Videos

Humanized NOG Mice Intravaginal HIV Exposure HIV Infection Preclinical HIV Research Viral Strains HIV Interventions CCR5 Variant Viral RNA Quantification Cord Blood Screening CCR5 Delta 32 HIV Exposure Protocol

Read Article

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Summary

Automatically generated

Explore More Videos