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Pomalidomür tabanlı homo-PROTACs tarafından E3 Ubiquitin ligase Cereblon kimyasal Inaktivasyonu
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Chemistry
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JoVE Journal Chemistry
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Pomalidomür tabanlı homo-PROTACs tarafından E3 Ubiquitin ligase Cereblon kimyasal Inaktivasyonu

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12,752 Views

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10:44 min

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May 15, 2019

DOI:

10.3791/59472-v

DOI:
10.3791/59472-v

•

10:44 min
May 15, 2019

•

17 Views
, , , , ,
1Department of Internal Medicine III,University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I,University of Bonn

Summary

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Bu çalışma, bir pomalidomür bazlı sentez ve karakterizasyon açıklar, yeni bir yaklaşım olarak bir roman yaklaşımı ve E3 Ubiquitin ligaz cereblon (CRBN), thalidomür analogların hedefi bozulması teşvik etmek.

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Cite this Article

Lindner, S., Steinebach, C., Kehm, H., Mangold, M., Gütschow, M., Krönke, J. Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs. J. Vis. Exp. (147), e59472, doi:10.3791/59472 (2019).

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