Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Simone Chiola; Manuela Santo; Antonello Mallamaci

doi:10.3791/59242

Journal

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Genetics

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Trasplante Intraventricular de Precursores Neuronales Deingidos para Estudios de Neuroarquitectura In Vivo

JoVE Journal
Genetics
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JoVE Journal Genetics

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

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Trasplante Intraventricular de Precursores Neuronales Deingidos para Estudios de Neuroarquitectura In Vivo

5,577 Views

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15:00 min

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May 11, 2019

DOI:

10.3791/59242-v

DOI:

10.3791/59242-v

•

15:00 min

May 11, 2019

•

2 Views

Simone Chiola¹, Manuela Santo¹, Antonello Mallamaci¹

¹Laboratory of Cerebral Cortex Development,SISSA

Summary

Basado en la ingeniería lentiviral in vitro de precursores neuronales, su co-trasplante en cerebros de tipo salvaje y evaluación morfométrica emparejada de derivados de "prueba" y "control", este método permite el modelado preciso del control genético in vivo del neocortical morfología de las neuronas de una manera simple y asequible.

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Trasplante Intraventricular de Precursores Neuronales Deingidos para Estudios de Neuroarquitectura In Vivo

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Summary

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