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Transplante intraventricular de precursores neuronais projetados para estudos de Neuroarquitetura in vivo
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Genetics
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JoVE Journal Genetics
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Transplante intraventricular de precursores neuronais projetados para estudos de Neuroarquitetura in vivo

português

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5,577 Views

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15:00 min

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May 11, 2019

DOI:

10.3791/59242-v

DOI:
10.3791/59242-v

•

15:00 min
May 11, 2019

•

2 Views
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1Laboratory of Cerebral Cortex Development,SISSA

Summary

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Com base na engenharia lentivirais in vitro de precursores neuronais, seu cotransplante em cérebros de tipo selvagem e avaliação morfométrica pareada de derivados de "teste" e "controle", este método permite a modelagem precisa do controle genético in vivo de neokortikalny morfologia do neurônio de forma simples e acessível.

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Chiola, S., Santo, M., Mallamaci, A. Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies. J. Vis. Exp. (147), e59242, doi:10.3791/59242 (2019).

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