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Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
JoVE Journal
Genetik
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JoVE Journal Genetik
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

5,577 Views

15:00 min

May 11, 2019

DOI:

15:00 min
May 11, 2019

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Summary

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Based on in vitro lentiviral engineering of neuronal precursors, their co-transplantation into wild-type brains and paired morphometric evaluation of "test" and "control" derivatives, this method allows accurate modeling of in vivo gene control of neocortical neuron morphology in a simple and affordable way.

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