Journal
/
Biochemistry
/
Identification of Functional Protein Regions Through Chimeric Protein Construction
JoVE Journal
Biochemistry
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Biochemistry
Identification of Functional Protein Regions Through Chimeric Protein Construction

Identification of Functional Protein Regions Through Chimeric Protein Construction

English

Automatically Generated

10,179 Views

•

11:39 min

•

January 08, 2019

DOI:

10.3791/58786-v

DOI:
10.3791/58786-v

•

11:39 min
January 08, 2019

•

9 Views
, , ,
1Department of Cardiac Development and Remodelling,Max Planck Institute for Heart and Lung Research, 2Partner site Rhein-Main,German Centre for Cardiovascular Research (DZHK)

Summary

Automatically generated

Structurally related proteins frequently exert distinct biological functions. The exchange of equivalent regions of these proteins in order to create chimeric proteins constitutes an innovative approach to identify critical protein regions that are responsible for their functional divergence.

Explore More Videos

Protein ChimeraFunctional Protein RegionsProtein StructureProtein SequenceProtein EngineeringMolecular BiologyStructural BiologyProtein Domain ExchangeProtein Domain Swapping

Read Article

Cite this Article

Adrian-Segarra, J. M., Lörchner, H., Braun, T., Pöling, J. Identification of Functional Protein Regions Through Chimeric Protein Construction. J. Vis. Exp. (143), e58786, doi:10.3791/58786 (2019).

Download .ris file

Copy

Share Video

.

Copy