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Identification of Functional Protein Regions Through Chimeric Protein Construction
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Journal JoVE Biochimie
Identification of Functional Protein Regions Through Chimeric Protein Construction

Identification of Functional Protein Regions Through Chimeric Protein Construction

10,179 Views

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11:39 min

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January 08, 2019

DOI:

10.3791/58786-v

DOI:
10.3791/58786-v

•

11:39 min
January 08, 2019

•

9 Views
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1Department of Cardiac Development and Remodelling,Max Planck Institute for Heart and Lung Research, 2Partner site Rhein-Main,German Centre for Cardiovascular Research (DZHK)

Summary

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Structurally related proteins frequently exert distinct biological functions. The exchange of equivalent regions of these proteins in order to create chimeric proteins constitutes an innovative approach to identify critical protein regions that are responsible for their functional divergence.

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Adrian-Segarra, J. M., Lörchner, H., Braun, T., Pöling, J. Identification of Functional Protein Regions Through Chimeric Protein Construction. J. Vis. Exp. (143), e58786, doi:10.3791/58786 (2019).

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