Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS <i>via</i> the Internal Carotid Artery

Ana R. Leda; Levy Dygert; Luc Bertrand; Michal Toborek

doi:10.3791/54804

Journal

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Neuroscience

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Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

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Neuroscience

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JoVE Journal Neuroscience

Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

10,629 Views

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06:41 min

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January 31, 2017

DOI:

10.3791/54804-v

DOI:

10.3791/54804-v

•

06:41 min

January 31, 2017

•

8 Views

Ana R. Leda¹, Levy Dygert¹, Luc Bertrand¹, Michal Toborek^1,2

¹Department of Biochemistry and Molecular Biology, Miller School of Medicine,University of Miami, ²The Jerzy Kukuczka Academy of Physical Education

Summary

The present protocol describes a mouse microsurgery infusion technique, which effectively delivers substances directly into the brain via the internal carotid artery.

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Mouse Microsurgery Infusion Technique Targeted Substance Delivery CNS Internal Carotid Artery Neuroscience Drug Delivery Pathogen Exosome Minimal Trauma Neuronal Network Brain Concentration Anesthesia Surgical Procedure Common Carotid Artery External Carotid Artery Internal Carotid Artery Vessel Clips

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Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

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