A subscription to JoVE is required to view this content. Sign in or start your free trial.
14,485 Views
•
09:22 min
•
June 22, 2015
DOI:
Summary
Automatically generated
This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.
Read Article
Cite this Article
Robinson, S., Adelman, J. S. A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning. J. Vis. Exp. (100), e52859, doi:10.3791/52859 (2015).
Copy