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Een methode voor het op afstand zwijgen neurale activiteit in Knaagdieren Tijdens Discrete Fasen van het Leren
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Behavior
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JoVE Journal Behavior
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
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Een methode voor het op afstand zwijgen neurale activiteit in Knaagdieren Tijdens Discrete Fasen van het Leren

Nederlands

Automatically Generated

14,485 Views

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09:22 min

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June 22, 2015

DOI:

10.3791/52859-v

DOI:
10.3791/52859-v

•

09:22 min
June 22, 2015

•

6 Views
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1Department of Neuroscience,Oberlin College

Summary

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This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.

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PharmacogeneticsDesigner-Receptors-Exclusively-Activated-by-Designer-DrugsSensory PreconditioningViral-mediated DeliveryInhibitory G-protein Coupled ReceptorNeuronal Activity SilencingLearning And MemoryBehavioral ParadigmBrain Region TargetingDose-dependent Effects

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Cite this Article

Robinson, S., Adelman, J. S. A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning. J. Vis. Exp. (100), e52859, doi:10.3791/52859 (2015).

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