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Um método para a atividade neural remotamente Silenciando em Roedores Durante fases distintas de Aprendizagem
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Behavior
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JoVE Journal Behavior
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Um método para a atividade neural remotamente Silenciando em Roedores Durante fases distintas de Aprendizagem

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14,485 Views

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09:22 min

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June 22, 2015

DOI:

10.3791/52859-v

DOI:
10.3791/52859-v

•

09:22 min
June 22, 2015

•

6 Views
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1Department of Neuroscience,Oberlin College

Summary

Automatically generated

This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.

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PharmacogeneticsDesigner-Receptors-Exclusively-Activated-by-Designer-DrugsSensory PreconditioningViral-mediated DeliveryInhibitory G-protein Coupled ReceptorNeuronal Activity SilencingLearning And MemoryBehavioral ParadigmBrain Region TargetingDose-dependent Effects

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Cite this Article

Robinson, S., Adelman, J. S. A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning. J. Vis. Exp. (100), e52859, doi:10.3791/52859 (2015).

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