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Immunology and Infection
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Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

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15,538 Views

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12:52 min

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September 09, 2014

DOI:

10.3791/51601-v

DOI:
10.3791/51601-v

•

12:52 min
September 09, 2014

•

4 Views
, ,
1Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection,Imperial College London, 2Département de Biologie du Développement et des Cellules Souches,Institut Pasteur, Unité Macrophages et Développement de l’Immunité

Summary

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To counteract pathogen dissemination, host cells reorganize their cytoskeleton to compartmentalize bacteria and induce autophagy. Using Shigella infection of tissue culture cells, host and pathogen determinants underlying this process are identified and characterized. Using zebrafish models of Shigella infection, the role of discovered molecules and mechanisms are investigated in vivo.

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Mazon Moya, M. J., Colucci-Guyon, E., Mostowy, S. Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions. J. Vis. Exp. (91), e51601, doi:10.3791/51601 (2014).

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