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Journal / Immunology and Infection / Use of Shigella flexneri to Study…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
 

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Article DOI: 10.3791/51601-v • 12:52 min • September 9th, 2014
September 9th, 2014 •
1, 2, 1
1Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, 2Département de Biologie du Développement et des Cellules Souches, Institut Pasteur, Unité Macrophages et Développement de l'Immunité

Capitoli

Riepilogo
Automatic Translation

To counteract pathogen dissemination, host cells reorganize their cytoskeleton to compartmentalize bacteria and induce autophagy. Using Shigella infection of tissue culture cells, host and pathogen determinants underlying this process are identified and characterized. Using zebrafish models of Shigella infection, the role of discovered molecules and mechanisms are investigated in vivo.

Tags

Shigella Flexneri Autophagy-cytoskeleton Interactions Intracellular Pathogen Phagosomes Cytosol Host Actin Cytoskeleton Motility And Dissemination Actin-based Motility Autophagy Cell Autonomous Immunity Septin Cages Filamentous GTP-binding Proteins Monitor Autophagy-cytoskeleton Interactions Tissue Culture Cells Zebrafish Larvae Bacterial Dissemination
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