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方法研究抗精神病药物的作用机制在<em>秀丽隐杆线虫</em
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JoVE Journal Neuroscience
Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
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方法研究抗精神病药物的作用机制在<em>秀丽隐杆线虫</em

DOI:
10.3791/50864-v

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07:35 min

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February 04, 2014

•

,
1Department of Psychiatry,Harvard Medical School, 2Mailman Research Center,McLean Hospital

Chapters

  • 00:05Title
  • 01:11Preparing the Drug Assay Plates
  • 02:37Assessing the Lethality and Developmental Delay
  • 04:53Assaying Pharyngeal Pumping
  • 05:55Assay Results from Clozapine Exposure
  • 07:08Conclusion

Summary

Automatic Translation

Automatic Translation

方法用于测试的抗精神病药物（APD）提供在秀丽隐杆线虫的效果表现出来。分析描述了用于测试的发展和生存能力和咽抽水率药物作用。这些方法也适用于药理学实验与比APD的其他类药物。

Tags

Caenorhabditis ElegansAntipsychotic DrugsPharmacogenetic StudiesDevelopmental AssayPharyngeal PumpingNeurotransmitter SynthesisSynaptic Structure And FunctionForward And Reverse Genetic ScreensChemical Genetic Screens

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