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Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
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Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

11,357 Views

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07:35 min

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February 04, 2014

DOI:

10.3791/50864-v

DOI:
10.3791/50864-v

•

07:35 min
February 04, 2014

•

6 Views
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1Department of Psychiatry,Harvard Medical School, 2Mailman Research Center,McLean Hospital

Summary

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Approaches for testing the effects of antipsychotic drugs (APDs) in Caenorhabditis elegans are demonstrated. Assays are described for testing drug effects on development and viability and on pharyngeal pumping rate. These methods are also applicable for pharmacogenetic experiments with drug classes other than APDs.

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Cite this Article

Hao, L., Buttner, E. A. Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans. J. Vis. Exp. (84), e50864, doi:10.3791/50864 (2014).

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