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在体内成像方法区分急性和慢性炎症
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Immunology and Infection
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JoVE Journal Immunology and Infection
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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在体内成像方法区分急性和慢性炎症

DOI:
10.3791/50690-v

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07:10 min

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August 16, 2013

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,
1Lurie Family Imaging Center, Dana-Farber Cancer Institute,Harvard Medical School, 2Division of Pediatric Hematology/Oncology/Stem Cell Transplantation,Columbia University Medical Center

Chapters

  • 00:05Title
  • 01:55Subcutaneous PMA Inflammation Model
  • 02:58Bioluminescence Imaging of Inflammation
  • 05:11Results: Longitudinal Bioluminescence Imaging of Inflammation
  • 06:39Conclusion

Summary

Automatic Translation

Automatic Translation

我们描述了一种非侵入性的成像方法，用于区分炎症阶段。系统交付鲁米诺揭示中性粒细胞MPO活性依赖于急性炎症。与此相反，注射光泽精允许可视化PHOX在巨噬细胞的活性依赖于慢性炎症。

Tags

InflammationAcute InflammationChronic InflammationNeutrophilsMacrophagesBioluminescence ImagingLuminolLucigeninMyeloperoxidase (MPO)Phagocyte NADPH Oxidase (Phox)Non-invasive ImagingPathogen Invasion

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