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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

19,914 Views

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07:10 min

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August 16, 2013

DOI:

10.3791/50690-v

DOI:
10.3791/50690-v

•

07:10 min
August 16, 2013

•

3 Views
,
1Lurie Family Imaging Center, Dana-Farber Cancer Institute,Harvard Medical School, 2Division of Pediatric Hematology/Oncology/Stem Cell Transplantation,Columbia University Medical Center

Summary

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We describe a non-invasive imaging method for distinguishing inflammatory stages. Systemic delivery of luminol reveals areas of acute inflammation dependent upon MPO activity in neutrophils. In contrast, injection of lucigenin allows for visualization of chronic inflammation dependent upon Phox activity in macrophages.

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InflammationAcute InflammationChronic InflammationNeutrophilsMacrophagesBioluminescence ImagingLuminolLucigeninMyeloperoxidase (MPO)Phagocyte NADPH Oxidase (Phox)Non-invasive ImagingPathogen Invasion

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Cite this Article

Tseng, J., Kung, A. L. In vivo Imaging Method to Distinguish Acute and Chronic Inflammation. J. Vis. Exp. (78), e50690, doi:10.3791/50690 (2013).

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