Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Conrad T. Pfeiffer; Christian E. Schafmeister

doi:10.3791/4112

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Biology

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

JoVE Journal
Biology

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JoVE Journal Biology

Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

24,178 Views

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11:42 min

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May 15, 2012

DOI:

10.3791/4112-v

DOI:

10.3791/4112-v

•

11:42 min

May 15, 2012

•

4 Views

Conrad T. Pfeiffer¹, Christian E. Schafmeister¹

¹College of Science and Technology,Temple University

Summary

The efficient solid-phase peptide synthesis of a functionalized bis-peptide trimer utilizing a "safety catch" cleavage procedure from HMBA resin is described.

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Solid-phase Synthesis Functionalized Bis-peptide Safety Catch Methodology R.B. Merrifield Solid Support Protecting Groups Coupling Methods Boc-based Protection Base/nucleophile Cleavable Resin Strategy Fmoc-based Protection Acidic Cleavable Resin Strategy Peptides Boc/tert-butyl Solid-phase Synthesis Strategy Bis-peptide Libraries Cleavage Stage Diketopiperazine Formation

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

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