Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Conrad T. Pfeiffer; Christian E. Schafmeister

doi:10.3791/4112

Journal

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生物学

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

JoVE 杂志
生物学

This content is Free Access.

JoVE 杂志生物学

Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

24,178 Views

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11:42 min

•

May 15, 2012

DOI:

10.3791/4112-v

DOI:

10.3791/4112-v

•

11:42 min

May 15, 2012

•

4 Views

Conrad T. Pfeiffer¹, Christian E. Schafmeister¹

¹College of Science and Technology,Temple University

Summary

The efficient solid-phase peptide synthesis of a functionalized bis-peptide trimer utilizing a "safety catch" cleavage procedure from HMBA resin is described.

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Solid-phase Synthesis Functionalized Bis-peptide Safety Catch Methodology R.B. Merrifield Solid Support Protecting Groups Coupling Methods Boc-based Protection Base/nucleophile Cleavable Resin Strategy Fmoc-based Protection Acidic Cleavable Resin Strategy Peptides Boc/tert-butyl Solid-phase Synthesis Strategy Bis-peptide Libraries Cleavage Stage Diketopiperazine Formation

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using “Safety Catch” Methodology

Summary

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