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秀丽隐杆线虫 作为发现生物活性化合物对抗聚谷氨酰胺介导的神经毒性的模型系统
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JoVE Journal Nörobilim
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
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秀丽隐杆线虫 作为发现生物活性化合物对抗聚谷氨酰胺介导的神经毒性的模型系统

DOI:
10.3791/63081-v

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08:16 min

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September 21, 2021

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, , , , , ,
1Institute for Food Nutrition and Human Health, School of Food Science and Engineering,South China University of Technology, 2School of Bioscience and Bioengineering,Hebei University of Economics and Business, 3Perfect Life & Health Institute

Bölümler

  • 00:05Introduction
  • 01:12PolyQ Aggregation Assay
  • 03:29PolyQ-Mediated Neurotoxicity Assays
  • 06:18Results: Analysis of the Overall Neuroprotective Capacity of Astragalan and its Effect on PolyQ40 Aggregation, Neuronal Death, and Behavioral Dysfunction
  • 07:51Conclusion

Özet

Otomatik Çeviri

Otomatik Çeviri

在这里，我们提出了一个方案来评估 秀丽隐杆线虫中测试化合物的神经保护活性，包括聚谷氨酰胺聚集，神经元死亡和化学避免行为，以及多种表型的示例性整合。

Etiketler

C. ElegansPolyglutamineNeurotoxicityHuntington’s DiseaseAnimal ModelHigh-throughput ScreeningPolyglutamine AggregatesFluorescence ImagingImage Analysis

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