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Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model
JoVE Journal
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JoVE Journal Davranış
Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

17,015 Views

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05:38 min

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January 07, 2019

DOI:

10.3791/58653-v

DOI:
10.3791/58653-v

•

05:38 min
January 07, 2019

•

33 Views
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1State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science,Nankai University

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We describe establishment of a murine model for Parkinson's disease using MPTP, and behavioral assessments using cylinder and open field tests to measure motor function. We then use L-DOPA as one example to show how to apply this model in the study of PD drugs.

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Jiang, P., Lang, Q., Yu, Q., Tang, X., Liu, Q., Li, X., Feng, X. Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model. J. Vis. Exp. (143), e58653, doi:10.3791/58653 (2019).

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