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Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model
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JoVE Journal 行動学
Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

DOI:
10.3791/58653-v

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05:38 min

•

January 07, 2019

•

, , , , , ,
1State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science,Nankai University

章

  • 00:04標題
  • 00:42Cylinder Test
  • 02:44Open Field Test
  • 03:36Results: Performance on the Cylinder and Open Field Tests Following MPTP Administration
  • 04:49Conclusion

概要

自動翻訳

自動翻訳

We describe establishment of a murine model for Parkinson's disease using MPTP, and behavioral assessments using cylinder and open field tests to measure motor function. We then use L-DOPA as one example to show how to apply this model in the study of PD drugs.

タグ

Behavioral AssessmentSpontaneous LocomotionMPTP-inducedParkinson’s Disease ModelCylinder TestOpen Field TestPaw LiftMotor FunctionL-DOPAVideo RecordingEnvironmental InterferenceAcclimationSanitization

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