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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
JoVE Journal
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JoVE Journal Biyokimya
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

8,728 Views

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09:57 min

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December 23, 2016

DOI:

10.3791/54722-v

DOI:
10.3791/54722-v

•

09:57 min
December 23, 2016

•

3 Views
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1Department of Biochemistry & Molecular Medicine,University of California, Davis, 2UC Davis Comprehensive Cancer Center,University of California, Davis, 3Department of Internal Medicine, Division of Hematology and Oncology,University of California, Davis

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To deliver cancer drugs to tumor sites with high specificity and reduced side effects, new methods based on nanoparticles are required. Here, we describe disulfide cross-linked micelles that can be easily prepared by hydrogen peroxide-mediated oxidation and are able to dissociate efficiently under a reducing tumor environment to release payloads.

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Li, Y., Bharadwaj, G., Lee, J. S. A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles. J. Vis. Exp. (118), e54722, doi:10.3791/54722 (2016).

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