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A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
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A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

DOI:
10.3791/56772-v

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05:54 min

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December 29, 2017

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1Department of Integrative Biology and Physiology,University of California, 2Center for Duchenne Muscular Dystrophy,University of California, 3Department of Neurology,David Geffen School of Medicine, University of California, 4Molecular Biology Institute,University of California

Capítulos

  • 00:05Título
  • 00:43Chamber Preparation, Muscle Activation, and Ambulation Recording
  • 01:50Video Analysis
  • 03:28Results: Analysis of mdx Ambulation and Representative Effects of Exercise
  • 05:16Conclusion

Summary

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This protocol describes a flexible, low-cost system for measuring mouse ambulation in an open field activity assay. We show that a 6-minute ambulation assay based on this system detects a decrease in voluntary movement in mdx mice, and accurately distinguishes improvement in a muscle-specific rescue of these animals.

Tags

Muscular DystrophyMouse ModelAmbulationActivityGrip StrengthVideo TrackingNon-invasiveReproducible

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