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A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
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JoVE Journal 行動学
A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

DOI:
10.3791/56772-v

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05:54 min

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December 29, 2017

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,
1Department of Integrative Biology and Physiology,University of California, 2Center for Duchenne Muscular Dystrophy,University of California, 3Department of Neurology,David Geffen School of Medicine, University of California, 4Molecular Biology Institute,University of California

章

  • 00:05標題
  • 00:43Chamber Preparation, Muscle Activation, and Ambulation Recording
  • 01:50Video Analysis
  • 03:28Results: Analysis of mdx Ambulation and Representative Effects of Exercise
  • 05:16Conclusion

概要

自動翻訳

自動翻訳

This protocol describes a flexible, low-cost system for measuring mouse ambulation in an open field activity assay. We show that a 6-minute ambulation assay based on this system detects a decrease in voluntary movement in mdx mice, and accurately distinguishes improvement in a muscle-specific rescue of these animals.

タグ

Muscular DystrophyMouse ModelAmbulationActivityGrip StrengthVideo TrackingNon-invasiveReproducible

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