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A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
JoVE Journal
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JoVE Journal Davranış
A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

9,733 Views

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05:54 min

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December 29, 2017

DOI:

10.3791/56772-v

DOI:
10.3791/56772-v

•

05:54 min
December 29, 2017

•

2 Views
,
1Department of Integrative Biology and Physiology,University of California, 2Center for Duchenne Muscular Dystrophy,University of California, 3Department of Neurology,David Geffen School of Medicine, University of California, 4Molecular Biology Institute,University of California

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This protocol describes a flexible, low-cost system for measuring mouse ambulation in an open field activity assay. We show that a 6-minute ambulation assay based on this system detects a decrease in voluntary movement in mdx mice, and accurately distinguishes improvement in a muscle-specific rescue of these animals.

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Cite this Article

Gibbs, E. M., Crosbie-Watson, R. H. A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy. J. Vis. Exp. (130), e56772, doi:10.3791/56772 (2017).

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