Journal
/
/
使用设计的混合工艺实验和自验证集成模型 (SVEM) 优化脂质纳米颗粒 (LNP) 配方的工作流程
JoVE 신문
화학
Author Produced
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 화학
A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

使用设计的混合工艺实验和自验证集成模型 (SVEM) 优化脂质纳米颗粒 (LNP) 配方的工作流程

DOI:

13:54 min

August 18, 2023

, , ,

Chapters

  • 00:04Introduction
  • 01:02Recording the Study Purpose, Responses, and Factors
  • 01:31Creation of the Design Table with a Space Filling Design
  • 04:08Running the Experiment
  • 04:22Analyzing the Experimental Results
  • 11:26Confirmation Runs
  • 12:26Representative Results
  • 13:30Conclusion

Summary

자동 번역

该协议提供了一种针对混合物,连续和分类研究因素进行配方优化的方法,可最大限度地减少实验设计构建中的主观选择。在分析阶段,采用有效且易于使用的建模拟合程序。

Related Videos

Read Article