È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.
A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
3,677 Views
•
13:54 min
•
August 18, 2023
DOI:
Summary
Automatically generated
This protocol provides an approach to formulation optimization over mixture, continuous, and categorical study factors that minimizes subjective choices in the experimental design construction. For the analysis phase, an effective and easy-to-use modeling fitting procedure is employed.
Read Article
Cite this Article
Karl, A. T., Essex, S., Wisnowski, J., Rushing, H. A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM). J. Vis. Exp. (198), e65200, doi:10.3791/65200 (2023).
Copy