This content is Free Access.
Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
2,217 Views
•
09:56 min
•
February 11, 2022
DOI:
Summary
Automatically generated
TGT surface is an innovative platform to study growth factor-integrin crosstalk. The flexible probe design, specificity of the adhesion ligand, and precise modulation of stimulation conditions allow robust quantitative assessments of EGFR-integrin interplay. The results highlight EGFR as a 'mechano-organizer' tuning integrin mechanics, influencing focal adhesion assembly and cell spreading.
Read Article
Cite this Article
Rao, T. C., Mattheyses, A. L. Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion. J. Vis. Exp. (180), e63529, doi:10.3791/63529 (2022).
Copy