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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

3,385 Views

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13:00 min

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July 31, 2021

DOI:

10.3791/62317-v

DOI:
10.3791/62317-v

•

13:00 min
July 31, 2021

•

8 Views
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1Division of Laboratory Animal Resources,Duke University Medical Center, 2Department of Pathology,Duke University Medical Center, 3Department of Immunology,Duke University Medical Center, 4Duke Human Vaccine Institute,Duke University Medical Center

Summary

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This article describes and demonstrates the administration of intranasal vaccines and the collection of milk from lactating rabbits (Oryctolagus cuniculus) as a means to assess mucosal immunity in a translationally appropriate model of maternal immunization.

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Maternal ImmunizationRabbit ModelIntranasal ImmunizationMilk CollectionAntibody TransferTransplacental Antibody TransferIgGIgANew Zealand White RabbitsPlacentationMaternal-fetal ImmunityNewborn ProtectionPassive Immunity

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Cite this Article

Landon, C. D., Dancourt, G., Shing, V., Staats, H. F. Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus). J. Vis. Exp. (173), e62317, doi:10.3791/62317 (2021).

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