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在免疫缺陷小鼠中表演人类骨骼肌异种移植物
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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
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在免疫缺陷小鼠中表演人类骨骼肌异种移植物

DOI:
10.3791/59966-v

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07:48 min

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September 16, 2019

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, , ,
1Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, 2Department of Neurology,Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience,Johns Hopkins University School of Medicine

Chapters

  • 00:04Title
  • 00:35Surgical Preparation
  • 01:48Xenograft Surgery
  • 03:52Xenograft Harvest
  • 05:43Results: Representative Human Skeletal Muscle Xenograft Analyses
  • 07:12Conclusion

Summary

자동 번역

자동 번역

在传统的实验室模型系统中，复杂的人类疾病对建模可能具有挑战性。在这里，我们描述了一种通过将人类骨骼肌活检移植到免疫缺陷小鼠中来模拟人类肌肉疾病的外科方法。

Tags

Human Skeletal Muscle XenograftsImmunodeficient MiceMuscle Disease ModelingPreclinical Therapeutic TestingHuman Muscle Cell BiologyRare Or Acquired Muscle DiseasesMuscle BiopsyNOD-Rag-gamma MouseTibialis AnteriorExtensor Digitorum LongusPeroneus LongusSurgical Procedure

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