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Journal / Chemistry / 不同二硫 Connectivities µ-芋螺毒素 PIIIA…
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JoVE Journal Chemistry
不同二硫 Connectivities µ-芋螺毒素 PIIIA 异构体的合成与结构测定
 
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不同二硫 Connectivities µ-芋螺毒素 PIIIA 异构体的合成与结构测定

Article DOI: 10.3791/58368-v • 11:44 min • October 2nd, 2018
October 2nd, 2018 •
*1, *1, *1, 1
1Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn
* These authors contributed equally

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富含半胱氨酸的肽折叠成不同的三维结构, 这取决于它们的二硫化物连通性。当缓冲氧化不导致所需的二硫化物连接时, 需要有针对性地合成单独的二硫化物异构体。该协议涉及 3-二硫键结合肽的选择性合成及其结构分析, 采用核磁共振和 ms/质谱研究。

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化学 问题 140 肽 半胱氨酸丰富 二硫化物连通性 合成 保护组策略 结构分析 2D 核磁共振 (核磁共振) ms/毫秒 (串联质谱)
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