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جيل المستمدة IPSC-Organoids الدماغ البشري لنموذج اضطرابات النمو العصبي في وقت مبكر
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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
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جيل المستمدة IPSC-Organoids الدماغ البشري لنموذج اضطرابات النمو العصبي في وقت مبكر

19,261 Views

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07:40 min

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April 14, 2017

DOI:

10.3791/55372-v

DOI:
10.3791/55372-v

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07:40 min
April 14, 2017

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16 Views
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1Center for Molecular Medicine Cologne,University of Cologne, 2Institute for Biochemistry I,Medical School of University of Cologne

Summary

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Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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IPSCBrain OrganoidsNeurodevelopmental DisordersNeurogenesisPrimary MicrocephalyNeurospheresEHS MatrixSpinner FlaskBrain Organoid MediumOrganoid Culture

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Cite this Article

Gabriel, E., Gopalakrishnan, J. Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders. J. Vis. Exp. (122), e55372, doi:10.3791/55372 (2017).

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