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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
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April 14, 2017
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Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.
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Gabriel, E., Gopalakrishnan, J. Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders. J. Vis. Exp. (122), e55372, doi:10.3791/55372 (2017).
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