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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
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December 27, 2016
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Biofilm infections show high tolerance towards chemotherapy. No single assay captures the complexity of biofilms. Instead, complementary assays are needed. We present a screening platform (developed for S. aureus) that combines assays for viability, biomass, and biofilm matrix. It allows anti-biofilm drug discovery, including the assessment of long-term chemotherapeutic effects.
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Skogman, M. E., Vuorela, P. M., Fallarero, A. A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries. J. Vis. Exp. (118), e54829, doi:10.3791/54829 (2016).
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