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Nanoparçacık Neurotoksite Belirleyen Bir Vekil Biosensor olarak mikroglia
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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
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Nanoparçacık Neurotoksite Belirleyen Bir Vekil Biosensor olarak mikroglia

6,831 Views

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08:37 min

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October 25, 2016

DOI:

10.3791/54662-v

DOI:
10.3791/54662-v

•

08:37 min
October 25, 2016

•

1 Views
, , , , ,
1Minneapolis Veterans Affairs Health Care System, 2Department of Food Science and Nutrition,University of Minnesota, 3Biomedical Informatics and Computational Biology Program,University of Minnesota, 4Minnesota Obesity Center,University of Minnesota

Summary

Automatically generated

Microglia (immune cells of the brain), are used as a surrogate biosensor to determine how nanoparticles influence neurotoxicity. We describe a series of experiments designed to assay microglial response to nanoparticles and exposure of hypothalamic neurons to supernatant from activated microglia to determine neurotoxicity.

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Cite this Article

Duffy, C. M., Ahmed, S., Yuan, C., Mavanji, V., Nixon, J. P., Butterick, T. Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity. J. Vis. Exp. (116), e54662, doi:10.3791/54662 (2016).

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