Journal
/
/
Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
JoVE 신문
신경과학
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 신경과학
Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

12,157 Views

09:36 min

May 12, 2014

DOI:

09:36 min
May 12, 2014

1 Views
, , ,

Summary

Automatically generated

Targeting brain-resident cells for direct lineage-reprogramming offers new perspectives for brain repair. Here we describe a protocol of how to prepare cultures enriched for brain-resident pericytes from the adult human cerebral cortex and convert these into induced neurons by retrovirus-mediated expression of the transcription factors Sox2 and Ascl1.

Read Article