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Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
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July 30, 2012
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The rapid development, small size and transparency of zebrafish are tremendous advantages for the study of innate immune control of infection1-4. Here we demonstrate techniques for infecting zebrafish larvae using the fungal pathogen Candida albicans by microinjection, methodology recently used to implicate phagocyte NADPH oxidase activity in control of fungal dimorphism5.
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Non-invasive ImagingDisseminated CandidiasisZebrafish LarvaeCandida AlbicansInnate ImmunityGenetic DefectsPhagocyte NADPH OxidaseDynamics Of C. Albicans InteractionMacrophagesNeutrophilsIn Vitro StudiesIn Vivo EnvironmentCytokine LevelsExtracellular Matrix AttachmentsIntercellular ContactsModel OrganismLive Intact HostZebrafish LarvaInnate Immune Defenses
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Brothers, K. M., Wheeler, R. T. Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae. J. Vis. Exp. (65), e4051, doi:10.3791/4051 (2012).
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