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Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
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JoVE Revista Inmunología y contagio
Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae

Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae

14,557 Views

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10:45 min

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July 30, 2012

DOI:

10.3791/4051-v

DOI:
10.3791/4051-v

•

10:45 min
July 30, 2012

•

4 Views
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1Department of Molecular and Biomedical Sciences,University of Maine

Summary

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The rapid development, small size and transparency of zebrafish are tremendous advantages for the study of innate immune control of infection1-4. Here we demonstrate techniques for infecting zebrafish larvae using the fungal pathogen Candida albicans by microinjection, methodology recently used to implicate phagocyte NADPH oxidase activity in control of fungal dimorphism5.

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Non-invasive ImagingDisseminated CandidiasisZebrafish LarvaeCandida AlbicansInnate ImmunityGenetic DefectsPhagocyte NADPH OxidaseDynamics Of C. Albicans InteractionMacrophagesNeutrophilsIn Vitro StudiesIn Vivo EnvironmentCytokine LevelsExtracellular Matrix AttachmentsIntercellular ContactsModel OrganismLive Intact HostZebrafish LarvaInnate Immune Defenses

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Cite this Article

Brothers, K. M., Wheeler, R. T. Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae. J. Vis. Exp. (65), e4051, doi:10.3791/4051 (2012).

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