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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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November 28, 2010
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To study in vivo tumor growth and tumor microenvironment, we used a syngeneic and orthotopic mouse model of ovarian cancer in immunocompetent animals. We transduced a mouse tumor cell line (MOV1) with Katushka fluorescent protein (MOV1KAT) and here we show its orthotopic implantation in ovary and in vivo imaging.
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Orthotopic ModelSerous Ovarian CancerImmunocompetent MiceIn Vivo Tumor ImagingTumor Immune ResponsesTg-MISIIR-TAg Transgenic Mouse ModelSV40 Transforming RegionMullerian Inhibitory Substance Type II Receptor (MISIIR) Gene PromoterSyngeneic Allograft RecipientsPreclinical StudiesTumor Microenvironment
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Nunez-Cruz, S., Connolly, D. C., Scholler, N. An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses. J. Vis. Exp. (45), e2146, doi:10.3791/2146 (2010).
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