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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
 

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Article DOI: 10.3791/1919-v • 07:28 min • April 29th, 2010
April 29th, 2010 •
1, 1
1Howard Hughes Medical Institute, Rockefeller University

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Automatic Translation

The fate of the replisome following a collision with a head-on RNA polymerase (RNAP) is unknown. We find that the replisome stalls upon collision with a head-on RNAP, but resumes elongation after displacing the RNAP from DNA. Mfd promotes replication restart by facilitating displacement of the RNAP after the collision.

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Replication Fork Head-on RNA Polymerase Replisome Transcription Complex DNA Displacement Stability Of Replication Fork Direct Restart Transcription-repair Coupling Factor Mfd Replication Apparatus Transcription-coupled Repair Pathway
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