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Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
JoVE Journal
Biochemistry
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JoVE Journal Biochemistry
Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

8,407 Views

08:56 min

September 15, 2021

DOI:

08:56 min
September 15, 2021

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Summary

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Here, we describe a protocol to create developmentally relevant human heart organoids (hHOs) efficiently using human pluripotent stem cells by self-organization. The protocol relies on the sequential activation of developmental cues and produces highly complex, functionally relevant human heart tissues.

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