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Journal / Developmental Biology / 生成基于人类 iPSC 的血脑屏障芯片
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JoVE Journal Developmental Biology
生成基于人类 iPSC 的血脑屏障芯片
 
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生成基于人类 iPSC 的血脑屏障芯片

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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血脑屏障（BBB）是一种多细胞神经血管单元，严密调节大脑平衡。通过结合人类 iPSC 和芯片上器官技术，我们生成了个性化的 BBB 芯片，适用于疾病建模和 CNS 药物渗透性预测。介绍了BBB芯片的生成和运行的详细方案。

Tags

发育生物学， 问题 157， 血脑屏障， BBB， 微流体， 芯片上器官， OoC， 神经血管单元， NVU， iPSC， iPS细胞， 星形细胞， 个性化医学， 精密医学
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