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膣内HIV曝露とHIV感染治療に対するヒト化NOGマウス

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Inmunología y contagio

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JoVE Revista Inmunología y contagio

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

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膣内HIV曝露とHIV感染治療に対するヒト化NOGマウス

8,296 Views

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08:15 min

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January 31, 2020

DOI:

10.3791/60723-v

DOI:

10.3791/60723-v

•

08:15 min

January 31, 2020

•

3 Views

Anna H. F. Andersen^1,2, Stine S. F. Nielsen^1,2, Rikke Olesen^1,2, Katharina Mack¹, Frederik Dagnæs-Hansen³, Niels Uldbjerg^1,4, Lars Østergaard^1,2, Ole S. Søgaard^1,2, Paul W. Denton^1,2,5, Martin Tolstrup^1,2

¹Department of Clinical Medicine,Aarhus University, ²Department of Infectious Diseases,Aarhus University Hospital, ³Department of Biomedicine,Aarhus University, ⁴Department of Gynecology and Obstetrics,Aarhus University Hospital, ⁵Department of Biology,University of Nebraska at Omaha

Summary

幹細胞移植、膣内ヒト免疫不全ウイルス暴露、液滴デジタルPCR RNAを用いたヒト化免疫不全ウイルス感染NOGマウスモデルの生成と評価のためのプロトコルを開発しました。定量化。

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